PMMA (poly methyl methacrylate), a well-known polymer of the methacrylate family, is widely utilized in biomedicine, particularly in odonatological applications like artificial teeth, dentures and denture bases, obturators, provisional or permanent crowns, and so on. The outstanding qualities of PMMA, such as its beauty, low density, and changeable mechanical properties, make it an ideal option for use in dentistry. The use of hybrid nanofillers comprising of zinc and zirconium oxides (ZrO2:ZnO) with PMMA and the investigation of the resulting changes in mechanical properties, compared to the addition of natural nano powder represented by nano bran (nB), was studied. The effect of introducing bran powder after turning it into a nanomaterial into PMMA and studying the change in mechanical characteristics was investigated. The use of these components lowers the cost of polymer formulations, allowing for the development of new biodegradable formulations and greatly lowering the environmental load on nature after using consumer items made from them. The bran powder material was added in different weight ratios (2%, 4%, 6%, 8%,10% and 12%), as well as ZrO2: ZnO as a hybrid nanofiller, which were added in the same proportions compared to the pure resin. An increase in the compressive strength was observed to reach its highest value at 206 Mpa of nB compared to the ZrO2:ZnO where it was 140 Mpa. As well as concerning flexibility, an increase in the elastic strength was observed where it was for ZrO2:ZnO and Bran respectively 68 Mpa and 88.98 Mpa compared to pure PMMA.