Nizhny Novgorod State Technical University n.a. R.E. Alekseev, Nizhny Novgorod, Russia.
10.30772/qjes.2025.163867.1690
Abstract
In this review article, various cutting-edge strategies are addressed that aim to enhance the mechanical and functional properties of Biocompatibility metal, which are manufactured using additive manufacturing techniques, in particular for biomedical applications such as implants and prostheses. Additive manufacturing has several advantages, including time saving and cost reduction, especially in small product manufacturing processes and prototypes, freedom of design for complex shapes that are difficult to achieve by traditional methods, the advantage of reducing waste and material waste, the possibility of customizing products to order, enhancing sustainability and reducing environmental impact, and others. It can be said that most of the previous studies focused either on the biological properties of biometallics that were manufactured using addition techniques or improving mechanical properties, while comprehensive strategies that integrate the two aspects together have not been reviewed, and this article shows how to achieve synergistic improvements between the two performances. Any modern integrative revision combines various strategies (alloying, microscopic, surface, computational).
H. H. Huang, L. J. Hargrove, M. Ortiz-Catalan, and J. W. Sensinger, “Integrating upper-limb prostheses with the human body: Technology advances, readiness, and roles in human–prosthesis interaction,” Annual Review of Biomedical Engineering, vol. 26, no. Volume 26, 2024, pp. 503–528, 2024. [Online]. Available: https://doi.org/10.1146/annurev-bioeng-110222-095816
M. H. Mobarak, M. A. Islam, N. Hossain, M. Z. Al Mahmud, M. T. Rayhan, N. J. Nishi, and M. A. Chowdhury, “Recent advances of additive manufacturing in implant fabrication – a review,” Applied Surface Science Advances, vol. 18, p. 100462, 2023. [Online]. Available: https://doi.org/10.1016/j.apsadv.2023.100462
Y. Wu, J. Liu, L. Kang, J. Tian, X. Zhang, J. Hu, Y. Huang, F. Liu, H. Wang, and Z. Wu, “An overview of 3d printed metal implants in orthopedic applications: Present and future perspectives,” Heliyon, vol. 9, no. 7, p. e17718, 2023. [Online]. Available: https://doi.org/10.1016/j.heliyon.2023.e17718
X. Tong, X. Hong, L. Chen, Y. Zhang, Y. Wang, Y. Chen, Y. Zhu, C. Wang, L. Zhu, J. Lin, S. Huang, J. Ma, and P. Luo, “Degradable zn–5ce alloys with high strength, suitable degradability, good cytocompatibility, and osteogenic differentiation fabricated via hot-rolling, hot-extrusion, and high-pressure torsion for potential load-bearing bone-implant application,” Journal of Materials Research and Technology, vol. 28, pp. 1752–1763, 2024. [Online]. Available: https://doi.org/10.1016/j.jmrt.2023.12.098
A. Daniel, S. Anand, J. Naveen, T. Khan, and S. Khahro, “Advancement in biomedical implant materials—a mini review,” Frontiers in Bioengineering and Biotechnology, vol. 12, 2024. [Online]. Available: https://doi.org/10.3389/fbioe.2024.1400918
K. Mosas, A. Chandrasekar, A. Dasan, A. Pakseresht, and D. Galusek, “Recent advancements in materials and coatings for biomedical implants,” Gels, vol. 8, no. 5, 2022. [Online]. Available: https://doi.org/10.3390/gels8050323
G. Tang, Z. Liu, Y. Liu, J. Yu, X. Wang, Z. Tan, and X. Ye, “Recent trends in the development of bone regenerative biomaterials,” Frontiers in Cell and Developmental Biology, vol. 9, p. 665813, 2021. [Online]. Available: https://doi.org/10.3389/fcell.2021.665813
Y. Ahmed, N. K. Ankah, N. Ogunlakin, I. ulhaq Toor, and W. Farooq, “Exploring the future of metallic implants: a review of biodegradable and non-biodegradable solutions,” Corrosion Reviews, vol. 43, no. 5, pp. 495–521, 2025. [Online]. Available: https://doi.org/10.1515/corrrev-2024-0125
C. Mocanu and C. Caltabellotta, “Biomaterials (metal/ceramic), advantages and disadvantages in medical prosthetics,” Medicine and materials, vol. 4, no. 3, pp. 141–148, 2024. [Online]. Available: https://doi.org/10.36868/MEDMATER.2024.04.03.141
M.-S. Baltatu, D.-D. Burduhos-Nergis, D. P. Burduhos-Nergis, and P. Vizureanu, “Advanced metallic biomaterials,” Materials research forum llc, vol. 118, no. 1, p. 162, 2022. [Online]. Available: https://doi.org/10.21741/9781644901779
M. Nikolova and M. Apostolova, “Advances in multifunctional bioactive coatings for metallic bone implants,” materials, vol. 16, no. 1, p. 183, 2023. [Online]. Available: https://doi.org/10.3390/ma16010183
H. D. Nguyen, A. Pramanik, A. Basak, Y. Dong, C. Prakash, S. Debnath, S. Shankar, I. Jawahir, S. Dixit, and D. Buddhi, “A critical review on additive manufacturing of ti-6al-4v alloy: microstructure and mechanical properties,” Journal of Materials Research and Technology, vol. 18, pp. 4641–4661, 2022. [Online]. Available: https://doi.org/10.1016/j.jmrt.2022.04.055
H. Zhang, B. Feng, D. Lin, W. Guo, Y. Cai, J. Xue, J. Aslam, Q. Song, B. Wang, and Z. Liu, “Enhanced mechanical properties of ti-6al-4v titanium alloy through laser-assisted burnishing,” The International Journal of Advanced Manufacturing Technology, vol. 135, no. 5, pp. 2635–2648, 2024. [Online]. Available: https://doi.org/10.21203/rs.3.rs-4773365/v1
G. Mani, D. Porter, S. Collins, T. Schatz, A. Ornberg, and R. Shulfer, “A review on manufacturing processes of cobalt-chromium alloy implants and their impact on corrosion resistance and biocompatibility,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 112, no. 6, p. e35431, 2024. [Online]. Available: https://doi.org/10.1002/jbm.b.35431
D. Smith, P. Pickett, T. Grabowski, J. Thorpe, and F. Azarmi, “Mechanical properties of cobalt chromium alloy manufactured by direct energy deposition technology,” Journal of Thermal Spray Technology, vol. 34, no. 2, pp. 674–689, 2025. [Online]. Available: https://doi.org/10.1007/s11666-024-01913-1
H. Al-Safi, S. M., L. E. A. Al-Jorani, A. K. J, and K. al azzawi, “Effect of adding chrome-cobalt, titanium, and tungsten alloys to cold-cure acrylic resin oral stent for cancer patients with head and neck radiotherapy,” Journal of Emergency Medicine, trauma and acute care, vol. 2024, no. 2, p. 11, 2024. [Online]. Available: https://doi.org/10.5339/jemtac.2024.uncidc.11
T. C. Dzogbewu and D. D. Beer, “powder bed fusion of multimaterials,” Journal of Manufacturing and Materials Processing, vol. 7, no. 1, p. 15, 2023. [Online]. Available: https://doi.org/10.3390/jmmp7010015
M. H. Sehhat and A. Mahdianikhotbesara, “powder spreading in laser-powder bed fusion process,” granular matter, vol. 23, no. 89, 2021. [Online]. Available: https://doi.org/10.1007/s10035-021-01162-x
R. Bidulsky, P. Petrousek, J. Bidulska, R. Hudak, J. zivcak, and M. Actis Grande, “Porosity quantification of additive manufactured ti6al4v and cocrw alloys produced by l-pbf,” Archives of Metallurgy and Materials, vol. vol. 67, no. No 1, pp. 83–89, 2022. [Online]. Available: https://doi.org/10.24425/amm.2022.137475
P. Petrousek, T. Kvackaj, J. Bidulska, R. Bidulsky, M. A. Grande, D. Manfredi, K.-P. Weiss, R. Kocisko, M. Luptak, and I. Pokorny, “Investigation of the properties of 316l stainless steel after am and heat treatment,” Materials, vol. 16, no. 11, 2023. [Online]. Available: https://doi.org/10.3390/ma16113935
G. O. Barrionuevo, M. Walczak, P. Mendez, I. La F ´e-Perdomo, E. Chiluisa-Palomo, W. Navas-Pinto, and D. E. Cree, “Effect of porosity on tribological properties of medical-grade 316l stainless steel manufactured by laser-based powder bed fusion,” Materials, vol. 18, no. 3, 2025. [Online]. Available: https://doi.org/10.3390/ma18030568
Y. K. Erdogan and B. Erkan, “Anodized nanostructured 316l stainless steel enhances osteoblast functions and exhibits anti-fouling properties,” ACS Biomaterials Science and Engineering, vol. 9, no. 2, pp. 693–704, 2023. [Online]. Available: https://doi.org/10.1021/acsbiomaterials.2c01072
V. Madhavadas, D. Srivastava, U. Chadha, S. Aravind Raj, M. T. H. Sultan, F. S. Shahar, and A. U. M. Shah, “A review on metal additive manufacturing for intricately shaped aerospace components,” CIRP Journal of Manufacturing Science and Technology, vol. 39, pp. 18–36, 2022. [Online]. Available: https://doi.org/10.1016/j.cirpj.2022.07.005
B. Blakey-Milner, P. Gradl, G. Snedden, M. Brooks, J. Pitot, E. Lopez, M. Leary, F. Berto, and A. du Plessis, “Metal additive manufacturing in aerospace: A review,” Materials Design, vol. 209, p. 110008, 2021. [Online]. Available: https://doi.org/10.1016/j.matdes.2021.110008
C. Zhao, B. Shi, S. Chen, D. Du, T. Sun, B. J. Simonds, K. Fezzaa, and A. D. Rollett, “Laser melting modes in metal powder bed fusion additive manufacturing,” Rev. Mod. Phys., vol. 94, p. 045002, Oct 2022. [Online]. Available: https://doi.org/10.1103/RevModPhys.94.045002
J. Cui, H. Liang, S. Chen, Y. Shao, H. Chen, and et al., “Recent progress and perspectives in laser additive manufacturing of biodegradable zinc alloy,” Journal of Materials Research and Technology, vol. 33, pp. 6958–6979, 2024. [Online]. Available: https://doi.org/10.1016/j.jmrt.2024.11.012
K. Tesaˇr, J. Lu ˇn ´a ˇckov ´a, M. Jex, M. ˇZaloudkov ´a, R. Vrbov ´a, M. Barto ˇs, P. Klein, L. Vi ˇstejnov ´a, J. Du ˇskov ´a, E. Filov ´a, Z. Sucharda, M. Steinerov ´a, S. Habr, K. Bal´ık, and A. Singh, “In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, zn alloying and polymer coating,” Journal of Magnesium and Alloys, vol. 12, no. 6, pp. 2472–2488, 2024. [Online]. Available: https://doi.org/10.1016/j.jma.2024.06.003
A. Boukalov ´a, J. Kub ´asek, D. Ne ˇcas, P. Min ´arik, ˇCrtomir Donik, D. Dvorsk ´y, D. Vojt ˇech, A. Michalcov ´a, M. Godec, and I. Paulin, “Harmonizing microstructures and enhancing mechanical resilience: Novel powder metallurgy approach for zn–mg alloys,” Journal of Materials Research and Technology, vol. 31, pp. 2807–2819, 2024. [Online]. Available: https://doi.org/10.1016/j.jmrt.2024.06.223
M.-M. Germaini, S. Belhabib, S. Guessasma, R. Deterre, P. Corre, and P. Weiss, “Additive manufacturing of biomaterials for bone tissue engineering– a critical review of the state of the art and new concepts,” Progress in Materials Science, vol. 130, p. 100963, 2022. [Online]. Available: https://doi.org/10.1016/j.pmatsci.2022.100963
Y. Chen, J. Lock, and H. H. Liu, “Chapter 9 - nanocomposites for cartilage regeneration,” Woodhead Publishing Series in Biomaterials, pp. 213–260, 2023. [Online]. Available: https://doi.org/10.1016/B978-0-12-818627-5.00018-X
A. Pandya, P. Upadhaya, S. Lohakare, T. Srivastava, S. Mhatre, S. Pulakkat, and V. B. Patravale, “Chapter 6 - nanobiomaterials for regenerative medicine,” Nanotechnology in Medicine and Biology, pp. 141–187, 2022. [Online]. Available: https://doi.org/10.1016/B978-0-12-819469-0.00007-1
R. Jairo and A. Gonzalez-Lizardo, “Plasma-treated polymeric biomaterials for improved surface and cell adhesion,” arxiv preprint arxiv, no. 6, p. 03883, 2025. [Online]. Available: https://doi.org/10.48550/arXiv.2504.03883
J. Mayers, B. Hofman, I. Sobiech, and M. Kwesiga, “Insights into the biocompatibility of biodegradable metallic molybdenum for cardiovascular applications-a critical review,” Frontiers in Bioengineering and Biotechnology, vol. 12, p. 1457553, 2024. [Online]. Available: https://doi.org/10.3389/fbioe.2024.1457553
J. K. Balangao, “Corrosion of metals: factors, types and prevention strategies,” Journal of Chemical Health Risks, vol. 14, no. 1, pp. 79–87, 2024. [Online]. Available: https://jchr.org/index.php/JCHR/article/view/2120
E. L. Medina, J. Vaca-Gonz ´alez, W. Aperador, S. Ramtani, C. Falentin-Daudre, and D. Garz ´on-Alvarado, “Review of advanced coatings for metallic implants: a study/proposal on yttria-stabilized zirconia and silver-doped hydroxyapatite,” JOM, vol. 77, p. 5345–5361, 2025. [Online]. Available: https://doi.org/10.1007/s11837-025-07345-8
Y. Xu, Y. Li, T. Chen, C. Dong, and X. B. K. Zhang, “A short review of medical-grade stainless steel: corrosion resistance and novel techniques,” Journal of Materials Research and Technology, vol. 29, pp. 2788–2798, 2024. [Online]. Available: https://doi.org/10.1016/j.jmrt.2024.01.240
F. Mart´ınez-P ´erez, “Corrosi ´on. tipos. prevenci ´on,” Revista Ciencias T ´ecnicas Agropecuarias, vol. 32, no. 2, jun. 2023. [Online]. Available: https://cu-id.com/2177/v32n2e10
M. Yi, W. Tang, Y. Zhu, C. Liang, Z. Tang, Y. Yin, W. He, S. Sun, and S. Su, “A holistic review on fatigue properties of additively manufactured metals,” Journal of Materials Processing Technology, vol. 329, p. 118425, 2024. [Online]. Available: https://doi.org/10.1016/j.jmatprotec.2024.118425
L. Zhou, J. Miller, J. Vezza, M. Mayster, M. Raffay, Q. Justice, Z. A. Tamimi, G. Hansotte, L. D. Sunkara, and J. Bernat, “Additive manufacturing: a comprehensive review,” Sensors, vol. 24, no. 9, p. 2668, 2024. [Online]. Available: https://doi.org/10.3390/s24092668
A. I. Saimon, E. Yangue, X. Yue, Z. J. Kong, and C. Liu, “Advancing additive manufacturing through deep learning: A comprehensive review of current progress and future challenges,” IISE Transactions, vol. 58, no. 1, pp. 33–56, 2026. [Online]. Available: https://doi.org/10.1080/24725854.2024.2443592
K. Janus, A. Jarzebska, A. Wojcik, A. Garbacz-Klempka, J. Piekło, S. Terlicka, M. Piekos, J. J. Sobczak, O. Krasa, and L. Krawczyk, “microstructure and mechanical properties of scalmalloy produced by selective laser melting in terms of long-term applications,” Archives of Civil and Mechanical Engineering, vol. 25, no. 4, p. 183, 2025. [Online]. Available: https://doi.org/10.1007/s43452-025-01242-2
Z. Fathipour, M. Hadi, O. Bayatb, and F. Fernandesc, “Improvement of surface properties and wear resistance of selective laser melting-fabricated inconel 625 alloy by ultrasonic nanocrystal surface modification for demanding applications,” Tribology transactions, vol. 68, no. 2, pp. 249–263, 2025. [Online]. Available: https://doi.org/10.1080/10402004.2025.2457970
C. Bulut, F. Yıldız, T. Varol, G. Kaya, and T. O. Erg ¨uder, “Effects of selective laser melting process parameters on structural, mechanical, tribological, and corrosion properties of cocrfemnni high entropy alloy,” Metals and Materials International, vol. 30, no. 1, pp. 2982–3004, 2024. [Online]. Available: https://doi.org/10.1007/s12540-024-01694-w
Y. Zhang, Y. Li, M. Song, Y. Li, S. Gong, and B. Zhang, “Tial alloy fabricated using electron beam selective melting: process, microstructure, and tensile performance,” Metals, vol. 14, no. 4, p. 482, 2024. [Online]. Available: https://doi.org/10.3390/met14040482
M.-H. T. Chen, Yi-Cheng and S.-F. Ou, “optimized laser surface remelting of 3d-printed ti6al4v manufactured through electron beam melting,” JOM, vol. 77, no. 2, pp. 481–493, 2025. [Online]. Available: https://doi.org/10.1007/s11837-024-06870-2
H. Hafizoglu, F. Memu, B. A. Hamat, H. E. Konokman, and N. Durlu, “Dynamic deformation behavior of the electron beam melted ti-6al-4v alloy,” Arabian Journal for Science and Engineering, vol. 50, no. 4, pp. 2541–2555, 2025. [Online]. Available: https://doi.org/10.1007/s13369-024-09166-4
J. A. Lee, J. Park, M. J. Sagong, S. Y. Ahn, J.-W. Cho, S. Lee, and H. S. Kim, “Active learning framework to optimize process parameters for additive-manufactured ti-6al-4v with high strength and ductility,” Nature communications, vol. 16, no. 1, p. 931, 2025. [Online]. Available: https://doi.org/10.1038/s41467-025-56267-1
S. Gain and D. Veeman, “A review on advances and challenges in wire arc additive manufacturing: process parameters, microstructural evolution and material performance across alloys,” Journal of alloys and compounds, vol. 1029, no. 1, p. 180735, 2025. [Online]. Available: https://doi.org/10.1016/j.jallcom.2025.180735
Y. Gao, W. Jiang, D. Zeng, X. Liang, C. Ma, and W. Xiao, “Additive manufacturing of titanium alloys for biomedical applications: A systematic review,” Review of Materials Research, vol. 1, no. 1, p. 100011, 2025. [Online]. Available: https://doi.org/10.1016/j.revmat.2025.100011
V. Goyal, G. Verma, and U. S. Dixit, “In-vitro study of ti6al4v alloy fabricated by laser-based additive manufacturing for orthopedic implant applications,” J Process Mechanical Engineering, 2024. [Online]. Available: https://doi.org/10.1177/09544089241289723
B. Jin, Q. Wang, L. Zhao, A. Pan, X. Ding, W. Gao, Y. Song, and X. Zhang, “A review of additive manufacturing techniques and post-processing for high-temperature titanium alloys,” Metals, vol. 13, no. 8, p. 1327, 2023. [Online]. Available: https://doi.org/10.3390/met13081327
Q. Wu, C. Qiao, Y. Wu, Z. Liu, X. Li, J. Wang, X. An, A. Huang, and C. V. S. Lim, “Numerical investigation on the reuse of recycled powders in powder bed fusion additive manufacturing,” Additive Manufacturing, vol. 77, p. 103821, 2023. [Online]. Available: https://doi.org/10.1016/j.addma.2023.103821
N. Zakerin, K. Morshed-Behbahani, D. P. Bishop, and A. Nasiri, “Review of tribological and wear behavior of alloys fabricated via directed energy deposition additive manufacturing,” Journal of Manufacturing and Materials Processing, vol. 9, no. 6, p. 194, 2025. [Online]. Available: https://doi.org/10.3390/jmmp9060194
Z. Liu, Q. Zhou, X. Liang, X. Wang, G. Li, K. Vanmeensel, and J. Xie, “Alloy design for laser powder bed fusion additive manufacturing: a critical review,” International Journal of Extreme Manufacturing, vol. 6, no. 2, p. 022002, jan 2024. [Online]. Available: https://doi.org/10.1088/2631-7990/ad1657
I. Ara, D. Bajwa, and A. Raeisi, “A review on the wear performance of additively manufactured 316l stainless steel: process, structure, and performance,” Journal of materials science, vol. 60, p. 5686–5720, 2025. [Online]. Available: https://doi.org/10.1007/s10853-025-10775-z
P. S. Humnabad, R. Tarun, and I. Das, “An overview of direct metal laser sintering (dmls) technology for metal 3d printing,” Journal of Mines, Metals and Fuels, vol. 70, no. 3A, pp. 127–133, 2022. [Online]. Available: https://doi.org/10.18311/jmmf/2022/30681
K. Wang, J. Yin, X. Chen, L. Wang, H. Xiao, X. Liu, and Z. Huang, “Advances on direct selective laser printing of ceramics: An overview,” Journal of Alloys and Compounds, vol. 975, p. 172821, 2024. [Online]. Available: https://doi.org/10.1016/j.jallcom.2023.172821
D. J. Liu, Yulin and F. Ning, “Sintering mechanisms in metal extrusion-based sintering-assisted additive manufacturing: State-of-the-art and perspectives,” Journal of Manufacturing Science and Engineering, vol. 147, no. 7, p. 070801, 2025. [Online]. Available: https://doi.org/10.1115/1.4068066
M.-A. Pastre, Y. Quinsat, and C. Lartigue, “Effects of additive manufacturing processes on part defects and properties: a classification review,” International Journal on Interactive Design and Manufacturing, vol. 16, no. 4, pp. 1471–1496, 2022. [Online]. Available: https://doi.org/10.1007/s12008-022-00839-8
L. Afroz, M. Qian, J. F. Y. Li, M. Easton, and R. Das, “Fatigue life of laser powder bed fusion (l-Pbf) alsi10mg alloy: effects of surface roughness and porosity,” Progress in additive manufacturing, vol. 10, no. 4, pp. 2423–2441, 2023. [Online]. Available: https://doi.org/10.2139/ssrn.4548909
S. Pourrahimi and L. A. Hof, “On the post-processing of complex additive manufactured metallic parts: a review,” Advanced engineering materials, vol. 26, no. 10, p. 2301511, 2024. [Online]. Available: https://doi.org/10.1002/adem.202301511
W. Huang, H. Garmestani, and S. Liang, “Microstructure evolution and the influence on residual stress in metal additive manufacturing with analytics,” Crystals, vol. 15, no. 5, p. 435, 2025. [Online]. Available: https://doi.org/10.3390/cryst15050435
S. G. Irizalp, N. Saklakoglu, C. Apaydin, and K. Ayan, “Effects of porosity and microstructure on the fatigue fracture properties of ti6al4v alloy produced through selective laser melting,” The International Journal of Advanced Manufacturing Technology, vol. 138, no. 5, pp. 2573–2589, 2025. [Online]. Available: https://doi.org/10.1007/s00170-025-15630-8
G. ´Alvarez, Z. Harris, K. Wada, C. Rodr´ıguez, and E. Mart´ınez-Pa ˜neda, “Hydrogen embrittlement susceptibility of additively manufactured 316l stainless steel: Influence of post-processing, printing direction, temperature, and pre-straining,” Additive Manufacturing, vol. 78, p. 103834, 2023. [Online]. Available: https://doi.org/10.1016/j.addma.2023.103834
T. Dusautoir, B. Berthel, S. Fouvry, P. Matzen, and D. Meck, “Influence of post-processing treatments on fatigue limit of notched additive manufactured ti-6al-4v determined by rapid thermographic methodology,” International journal of fatigue, vol. 179, p. 108034, 2024. [Online]. Available: https://doi.org/10.1016/j.ijfatigue.2023.108034
A. M. Mancisidor, M. B. Garc´ıa-Blanco, I. Quintana, P. J. Arrazola, E. Espinosa, M. Cuesta, J. Albizuri, and F. Garciandia, “Effect of post-processing treatment on fatigue performance of ti6al4v alloy manufactured by laser powder bed fusion,” Journal of Manufacturing and Materials Processing, vol. 7, no. 4, p. 119, 2023. [Online]. Available: https://doi.org/10.3390/jmmp7040119
A. Mostafaei, R. Ghiaasiaan, I.-T. Ho, S. Strayer, K.-C. Chang, N. Shamsaei, S. Shao, S. Paul, A.-C. Yeh, S. Tin, and A. C. To, “Additive manufacturing of nickel-based superalloys: A state-of-the-art review on process-structure-defect-property relationship,” Progress in Materials Science, vol. 136, p. 101108, 2023. [Online]. Available: https://doi.org/10.1016/j.pmatsci.2023.101108
J. Chen and B. Chen, “Progress in additive manufacturing of magnesium alloys: a review,” materials, vol. 17, no. 15, p. 3851, 2024. [Online]. Available: https://doi.org/10.3390/ma17153851
D. Tourret, R. Tavakoli, A. Boccardo, A. Boukellal, M. Li, and J. Molina-Aldareguia, “Emergence of rapid solidification microstructure in additive manufacturing of a magnesium alloy,” Modelling and Simulation in Materials Science and Engineering, vol. 32, p. 055012, 2024. [Online]. Available: https://doi.org/10.48550/arXiv.2404.16031
U. L. Lee, S. Yun, H. Lee, H. L. Cao, S. H. Woo, Y. H. Jeong, T. G. Jung, C. M. Kim, and P. H. Choung, “Osseointegration of 3d-printed titanium implants with surface and structure modifications,” Dental Materials, vol. 38, no. 10, pp. 1648–1660, 2022. [Online]. Available: https://doi.org/10.1016/j.dental.2022.08.003
C. Y. Lee, P. C. Kung, C. C. Huang, S. J. Shih, E. W. Huang, S. Y. Chen, M. H. Wu, and N. T. Tsou, “In vivo study of bone growth around additively manufactured implants with ti-6al-4v and bioactive glass powder composites,” J Orthop Res, vol. 43, no. 10, pp. 1796–1804, 2025. [Online]. Available: https://doi.org/10.1002/jor.70037
D. Tourret, R. Tavakoli, D. Boccardo, K. Boukellal, M. Li, and J. Molina-Aldareguia, “Emergence of rapid solidification microstructure in additive manufacturing of a magnesium alloy,” Modelling and simulation in materials science and engineering, vol. 32, no. 5, p. 055012, 2024. [Online]. Available: https://doi.org/10.48550/arXiv.2404.16031
K. K. Thomas, M. N. Zafar, W. G. Pitt, and G. A. Husseini, “Biodegradable magnesium alloys for biomedical implants: properties, challenges, and surface modifications with a focus on orthopedic fixation repair,” Applied sciences, vol. 14, no. 1, p. 10, 2023. [Online]. Available: https://doi.org/10.3390/app14010010
J. Liu, B. Liu, S. Min, B. Yin, B. Peng, Z. Yu, C. Wang, X. Ma, P. Wen, Y. Tian, and Y. Zheng, “Biodegradable magnesium alloy we43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation,” Bioactive Materials, vol. 16, pp. 301–319, 2022. [Online]. Available: https://doi.org/10.1016/j.bioactmat.2022.02.020
K. Xie, N. Wang, Y. Guo, S. Zhao, J. Tan, L. Wang, G. Li, J. Wu, Y. Yang, W. Xu, J. Chen, W. Jiang, P. Fu, and Y. Hao, “Additively manufactured biodegradable porous magnesium implants for elimination of implant-related infections: An in vitro and in vivo study,” Bioactive Materials, vol. 8, pp. 140–152, 2022. [Online]. Available: https://doi.org/10.1016/j.bioactmat.2021.06.032
S. Pattanayak, P. Dash, S. Satpathi, A. K. Sahoo, N. R. Das, B. Nayak, and S. K. Sahoo, “Additive manufacturing of 316l stainless steel orthopedic implant with improved in vitro hemocompatibility and hydrophilicity for osteoinduction in wistar rat model,” Biomaterials Advances, vol. 175, p. 214322, 2025. [Online]. Available: https://doi.org/10.1016/j.bioadv.2025.214322
S. Prakrathi, V. M. Dayasagar, G. D., Yashavantha, and Y. Singh, “A study on metal 3d printing of 316l stainless steel for biomedical implants,” International conference on additive manufacturing. Singapore: Springer Nature Singapore, vol. 1, pp. 1–7, 2024. [Online]. Available: https://doi.org/10.1007/978-981-97-6016-9 1
Y. K. Erdogan and B. Ercan, “Anodized nanostructured 316l stainless steel enhances osteoblast functions and exhibits anti-fouling properties,” ACS Biomaterials Science and Engineering, vol. 9, no. 2, pp. 693–704, 2023. [Online]. Available: https://doi.org/10.1021/acsbiomaterials.2c01072
Z. Wang, Y. Yuan, S.Zhang, Y. Lin, and J.Tan, “A multi-state fusion informer integrating transfer learning for metal tube bending early wrinkling prediction,” applied soft computing, vol. 151, p. 110991, 2024. [Online]. Available: https://doi.org/10.1016/j.asoc.2023.110991
H. Huang, P. Zhang, M. Tang, L. Shen, Z. Yu, H. Shi, and Y. Tian, “Biocompatibility of micro/nano structures on the surface of ti6al4v and ti-based bulk metallic glasses induced by femtosecond laser,” Biomaterials Advances, vol. 139, p. 212998, 2022. [Online]. Available: https://doi.org/10.1016/j.bioadv.2022.212998
H. Zhang, Z. Wu, Z. Wang, X. Yan, X. Duan, and H. Sun, “Advanced surface modification techniques for titanium implants: A review of osteogenic and antibacterial strategies,” Frontiers in Bioengineering and Biotechnology, vol. 13, no. 1, p. 1549439, 2025. [Online]. Available: https://doi.org/10.3389/fbioe.2025.1549439
S. E. Baakili, P. Munyensanga, M. Bricha, and K. E. Mabrouk, “Porous metallic implants from additive manufacturing to biocorrosion: A review,” Johnson Matthey Technology Review, vol. 68, no. 1, pp. 71–90, 2024. [Online]. Available: https://doi.org/10.1595/205651324X16826780236175
A. Padsalgikar, “Applications of polyurethanes in medical devices,” vol. ISBN: 9780128196731, no. 1st Edition, 2022.
Q. Zhong, X. Pan, Y. Chen, Q. Lian, J. Gao, Y. Xu, J. Wang, Z. Shi, and H. Cheng, “prosthetic metals: release, metabolism and toxicity,” international journal of nanomedicine, vol. 5, no. 19, pp. 5245–5267, 2024. [Online]. Available: https://doi.org/10.2147/ijn.s459255
L. Leila and M. Palmieri, “Review of the use of metals in biomedical applications: biocompatibility, additive manufacturing technologies, and standards and regulations,” metals, vol. 14, no. 9, p. 1039, 2024. [Online]. Available: https://doi.org/10.3390/met14091039
H.,A S. and Khlybov,A . (2026). Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review. Al-Qadisiyah Journal for Engineering Sciences, 19(1), 1-10. doi: 10.30772/qjes.2025.163867.1690
MLA
H.,A S., and Khlybov,A . "Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review", Al-Qadisiyah Journal for Engineering Sciences, 19, 1, 2026, 1-10. doi: 10.30772/qjes.2025.163867.1690
HARVARD
H. A S., Khlybov A. (2026). 'Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review', Al-Qadisiyah Journal for Engineering Sciences, 19(1), pp. 1-10. doi: 10.30772/qjes.2025.163867.1690
CHICAGO
A S. H. and A Khlybov, "Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review," Al-Qadisiyah Journal for Engineering Sciences, 19 1 (2026): 1-10, doi: 10.30772/qjes.2025.163867.1690
VANCOUVER
H. A S., Khlybov A. Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review. QJES. 2026;19(1):1-10. doi: 10.30772/qjes.2025.163867.1690