Al-Qadisiyah Journal for Engineering Sciences

Efficient Ibuprofen synthesis from isobutyl-benzene under ambient conditions

Document Type : Research Paper

Authors

Ghufran Alamri 1
Salih A. Rushdi 1
Zainab T. Al-sharify 2
Soumya Ghosh 3, 4

1 Department of Chemical Engineering, College of Engineering, University of Al-Qadisiyah, Qadisiyah 58002, Iraq.

2 Department of Environmental Engineering, College of Engineering, University of Mustansiriyah, Baghdad 10052, Iraq.

3 Natural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman.

4 University of the Free State, Bloemfontein 9301, South Africa.

10.30772/qjes.2024.147188.1141
Abstract
Ibuprofen is classified as a non-steroidal anti-inflammatory medication (NSAID). This medication is employed for the treatment of several ailments, encompassing mild to moderate pain such as toothache, migraine, and period pain. Additionally, it is used to alleviate high-temperature fevers resembling influenza, reduce inflammation in tissues, and manage conditions like rheumatoid arthritis, back pain, and gout, among others. Despite the relative simplicity of ibuprofen's structure, it possesses significant structural complexity to enable a broader variety of acquisition methods. Numerous techniques for acquiring it with possible industrial utility have been discovered since the inception of its initial commercial use. The majority of commercially viable industrial processes utilized for the synthesis of ibuprofen are derived from isobutyl-benzene (IBB). Commercial isobutyl benzene (IBB) is synthesized through the reaction between propene and toluene. The conversion of isobutyl benzene ranges from (18.05%) to (19.8%) at various values of reaction temperature and from the results we can see that the reaction time has a significant effect on the isobutyl benzene conversion.

Keywords

Ibuprofen
Isobutyl benzene
Conversion
Experimental design
BBD
Production
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Al-Qadisiyah Journal for Engineering Sciences
Volume 18, Issue 1
Winter 2025
Pages 36-39

  • Receive Date 09 February 2024
  • Revise Date 12 May 2024
  • Accept Date 25 August 2024

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